I’m not sure how he’d feel about that. I feel like being a werewolf is all Derek’s ever really known. And I think really early on in the first season when he tells Scott the bite is a gift, I think he’s always looked at it as a very positive thing. So I don’t know if it would be something that he’d be excited about..? But it would definitely be an interesting change. That would be such a vulnerable place for him to be. You know to have to deal with people having to kind of look after him now. And knowing that if something happens to you you’re not going to heal - Things like that. I think it would be a massive massive adjustment for him to make.
Tyler Hoechlin speaking at AlphaCon about the possibility of Derek becoming human (source)
(Source: notanotherteenwolfpodcast, via sinyhale)